Epiduo 0.1%/2.5% gel is used in treating acne or pimples. It contains a combination of two medicines - adapalene and benzoyl peroxide as active components. This gel must not be used if you are allergic to any of its components or are pregnant. It is meant only for external application and should be applied as recommended by your doctor. You may experience some application site reactions as side effects, but they normally fade away with time. Please report to your doctor if you notice the side effects persist or worsen.